Characterisation of a PIK3CA Mutation in Breast and Ovarian Cancer

Grant number: 628620 | Funding period: 2010 - 2012

Completed

Abstract

PIK3CA mutations are frequently found in breast and ovarian cancers but how they cause cancer is not clear. We will exploit a unique mouse model to investigate the functional effects of PIK3CA mutations in cells and their role in cancer development. Understanding the mechanisms by which PIK3CA mutations regulate cell function and drive tumour growth will allow the rationale design of novel anti-cancer agents that specifically target this important cancer pathway.

Related publications (5)

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Heterozygous expression of the oncogenic Pik3caH1047R mutation during murine development results in fatal embryonic and extraembryonic defects

LM Hare, Q Schwarz, S Wiszniak, R Gurung, KG Montgomery, CA Mitchell, WA Phillips

2015-08-01

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway regulates many cellular functions including proliferation, migration, ..

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Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

KM Kinross, KG Montgomery, SP Mangiafico, LM Hare, M Kleinschmidt, MJ Bywater, IJ Poulton, C Vrahnas, H Henneicke, J Malaterre, PM Waring, C Cullinane, NA Sims, GA McArthur, S Andrikopoulos, WA Phillips

2015-04-01

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most common mutations found in human can..

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Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

KE Sheppard, C Cullinane, KM Hannan, M Wall, J Chan, F Barber, J Foo, D Cameron, A Neilsen, P Ng, J Ellul, M Kleinschmidt, KM Kinross, DD Bowtell, JG Christensen, RJ Hicks, RW Johnstone, GA McArthur, RD Hannan, WA Phillips

2013-12-01

Background Ovarian cancer is the major cause of death from gynaecological malignancy with a 5 year survival of only ∼30% due to re..

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Physiological levels of Pik3caH1047R mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors

A Tikoo, V Roh, KG Montgomery, I Ivetac, P Waring, R Pelzer, L Hare, M Shackleton, P Humbert, WA Phillips

2012-05-30

PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors inc..

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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

KM Kinross, KG Montgomery, M Kleinschmidt, P Waring, I Ivetac, A Tikoo, M Saad, L Hare, V Roh, T Mantamadiotis, KE Sheppard, GL Ryland, IG Campbell, KL Gorringe, JG Christensen, C Cullinane, RJ Hicks, RB Pearson, RW Johnstone, GA McArthur

2012-02-01

Mutations in the gene encoding the p110α subunit of PI3K (PIK3CA) that result in enhanced PI3K activity are frequently observed in..

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